Following MI6's decision to issue a kill order on Hattie Shaw, the CIA enlisted Luke Hobbs and Deckard Shaw with locating Hattie and securing The Snowflake. Realizing that Hattie was not spotted by one of London's many security cameras, Hobbs intercepted Hattie on one of the few blind spots, where the pair fought. Both Hobbs and Hattie showed restraint during their fight before Hobbs defeated her and brought her into custody at a CIA black site in London. Hobbs attempted to interrogate her regarding the virus, notifying her that he believed that she had not killed her fellow agents. However, Hattie refused to speak with him, deducing that he was not a CIA agent as he lacked the physicality or subtlety, regarding him as a brute soldier rather than an agent. As Hobbs left the room, Hattie attacked the CIA agent guarding the room, forcing Hobbs to intervene.
As Luke Hobbs pulled a gun on Hattie, Deckard Shaw infiltrated the building, holding Hobbs at gunpoint and ordering him to lower his weapon. As the duo argued, the building was attacked by Eteon. Super soldier Brixton Lore subsequently kidnapped Hattie and jumped out the window, running down the building. Hobbs and Shaw decided to work together to liberate Hattie. After defeating the soldiers, Hobbs jumped out the window, with Deckard using an external elevator. Hattie managed to attack Brixton and free herself, and as Brixton prepared to retaliate, Hobbs crashed into Brixton. Hattie then fought and killed the remaining Eteon soldiers along with her brother, although the trio were unable to defeat the super soldier. Brixton and Deckard were shocked to see each other once more, although the three of them escaped Brixton and the other soldiers pursuing them in Deckard's McLaren 720S.
Upon successfully escaping Brixton Lore's pursuit, Hattie informed Luke Hobbs and Deckard Shaw that she had injected herself with The Snowflake and therefore only had less than two days left to live. Hobbs revealed that he had footage of someone who might be able to remove the virus, and upon showing the image to Deckard, discovered that the man, Professor Andreiko, was purchasing a newspaper found only in one area. Upon interrogating Andreiko, Hattie discovered that Andreiko had developed The Snowflake as a vaccine to aid humanity before Eteon had reprogrammed it to eliminate humans they had deemed weak, and that they had only two choices: either Hattie had to be killed with her body burnt without recognition, or they would have to use an extracting machine at Eteon's heavily guarded headquarters, with the trio choosing the latter option.